No. Derivative TD status permits residence and study but carries no work authorization at any stage, and no waiting period changes that. Employment of any kind inside the United States, including remote work for a Quebec employer performed from an American address, requires the spouse to hold a status of her own that allows it.
The derivative status is the quietest cost of this route
A household that moves on one professional’s admission often assumes the second earner will find something once settled. Under TD there is nothing to find. She may enrol in a course, the children may attend school, and none of them may be employed.
Two dates deserve attention before anyone signs a lease. A child ceases to qualify as a derivative on turning twenty-one, so a family with a nineteen-year-old should map that birthday against the expected length of the assignment rather than discovering it at renewal. And a common-law partner is not a spouse for these purposes, which matters more often in Quebec than elsewhere and means a separate basis would be needed.
Where the second income is not optional, it is worth comparing this route against the intracompany and treaty-investor categories, in which an accompanying spouse is employment-authorized incident to status.